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Article

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2003

Verma Udit N, Surabhi Rama M, Schmaltieg Aurelia, Becerra Carlos, Gaynor Richard B

Abstract excerpt

The beta-catenin and APC genes are key components of the Wnt signaling pathway. Mutation of these genes results in increased levels of the beta-catenin protein, which is associated with enhanced cellular proliferation and the development of both colon polyps and colon cancer. Recently, a techniqu...

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PMID: 12684397

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12684397-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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