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Article

Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling.

Journal of pineal research - 1 Aug 2022

Sokolov Daniil, Sharda Neha, Giri Banabihari, Hassan Md Sazzad, Singh Damandeep, Tarasiewicz Agnieszka, Lohr Charity, von Holzen Urs, Kristian Tibor, Waddell Jaylyn, Reiter Russel J, Ahmed Hafiz, Banerjee Aditi

Abstract excerpt

β-catenin signaling, and angiogenesis are associated with colospheroid (CSC), development. CSCs, spheroids derived from colon cancer cells, are responsible for metastasis, drug resistance, and disease recurrence. Whether dysregulating β-catenin and inhibiting angiogenesis reduce CSC growth is unknown. In this study, the molecular mechanism of CSC growth inhibition was evaluated using a novel combination of...

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Identifiers

PMID: 35619550
DOI: 10.1111/jpi.12808
PMCID: PMC9288490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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