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Article

Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.

Cancer letters - 28 Jan 2014

Pogribny Igor P, Rusyn Ivan

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC are extremely complicated and consist of prominent genetic, genomic, and epigenetic alterations. This review summarizes the current knowledge of the role of epigenetic aberrations, including changes in DNA methylation, histone modifications, and expression of...

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Carcinoma, Hepatocellular
Cell Transformation, Neoplastic
Epigenesis, Genetic
Histones
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms, Experimental

Predictive Value of Tests

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PMID: 22306342
DOI: 10.1016/j.canlet.2012.01.038
PMCID: PMC3971756

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