Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.

Current biology : CB - 10 May 2005

Todi Sokol V, Franke Josef D, Kiehart Daniel P, Eberl Daniel F

Abstract excerpt

In vertebrates, auditory and vestibular transduction occurs on apical projections (stereocilia) of specialized cells (hair cells). Mutations in myosin VIIA (myoVIIA), an unconventional myosin, lead to deafness and balance anomalies in humans, mice, and zebrafish; individuals are deaf, and stereocilia are disorganized. The exact mechanism through which myoVIIA mutations result in these inner-ear anomalies is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dyneins
Share to Ear, Inner
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Auditory

Share to Hair Cells, Auditory

Share to Intercellular Junctions

Share to Myosin VIIa

Share to Myosins

Source

Open in PubMed Open full text

Identifiers

PMID: 15886106
DOI: 10.1016/j.cub.2005.03.050
PMCID: PMC1808204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.PMID 15886106Read ↗

Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.Semantic proximity Read ↗

A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair CellsSemantic proximity Read ↗

Unconventional myosins and the genetics of hearing loss.Semantic proximity Read ↗

Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes.Semantic proximity Read ↗

Pathophysiology of human hearing loss associated with variants in myosinsSemantic proximity Read ↗

The Kinocilia of Cochlear Hair Cells: Structures, Functions, and DiseasesSemantic proximity Read ↗

Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish.Semantic proximity Read ↗

Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.Semantic proximity Read ↗

Mutations in Drosophila crinkled/Myosin VIIA disrupt denticle morphogenesis.Semantic proximity Read ↗

Molecular Specializations Underlying Phenotypic Differences in Inner Ear Hair Cells of Zebrafish and MiceSemantic proximity Read ↗

Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.Semantic proximity Read ↗

Myosins and deafness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.