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Article

Multiple rare alleles contribute to low plasma levels of HDL cholesterol.

Science (New York, N.Y.) - 6 Aug 2004

Cohen Jonathan C, Kiss Robert S, Pertsemlidis Alexander, Marcel Yves L, McPherson Ruth, Hobbs Helen H

Abstract excerpt

Heritable variation in complex traits is generally considered to be conferred by common DNA sequence polymorphisms. We tested whether rare DNA sequence variants collectively contribute to variation in plasma levels of high density lipoprotein cholesterol (HDL-C). We sequenced three candidate genes (ABCA1, APOA1, and LCAT) that cause Mendelian forms of low HDL-C levels in individuals from a population-based study....

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Source

Identifiers

PMID: 15297675
DOI: 10.1126/science.1099870

Genes

ABCA1
APOA1
LCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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