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Article

Population-based resequencing of APOA1 in 10,330 individuals: spectrum of genetic variation, phenotype, and comparison with extreme phenotype approach.

PLoS genetics - 1 Jan 2012

Haase Christiane L, Frikke-Schmidt Ruth, Nordestgaard Børge G, Tybjærg-Hansen Anne

Abstract excerpt

Rare genetic variants, identified by in-detail resequencing of loci, may contribute to complex traits. We used the apolipoprotein A-I gene (APOA1), a major high-density lipoprotein (HDL) gene, and population-based resequencing to determine the spectrum of genetic variants, the phenotypic characteristics of these variants, and how these results compared with results based on resequencing only the extremes of the...

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Identifiers

PMID: 23209431
DOI: 10.1371/journal.pgen.1003063
PMCID: PMC3510059

Genes

APOA1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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