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Article

Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission.

Journal of neurophysiology - 1 Mar 2008

Hickman John A, Hardwick J Marie, Kaczmarek Leonard K, Jonas Elizabeth A

Abstract excerpt

A role for BCL-xL in regulating neuronal activity is suggested by its dramatic effects on synaptic function and mitochondrial channel activity. When recombinant BCL-xL is injected into the giant presynaptic terminal of squid stellate ganglion or applied directly to mitochondrial outer membranes within the living terminal, it potentiates synaptic transmission acutely, and it produces mitochondrial channel...

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Identifiers

PMID: 18160428
DOI: 10.1152/jn.00598.2007
PMCID: PMC2836590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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