Article
Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.
Psychosomatic medicine - 1 Jan 2008
Williams Redford B, Marchuk Douglas A, Siegler Ilene C, Barefoot John C, Helms Michael J, Brummett Beverly H, Surwit Richard S, Lane James D, Kuhn Cynthia M, Gadde Kishore M, Ashley-Koch Allison, Svenson Ingrid K, Suarez Edward C, Schanberg Saul M
Abstract excerpt
OBJECTIVE: To test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. CVR to mental stress has been proposed as one mechanism linking stress to the pathogenesis of cardiovascular disease. The more transcriptionally efficient long...
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