Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.

Biological psychiatry - 1 May 2008

Gotlib Ian H, Joormann Jutta, Minor Kelly L, Hallmayer Joachim

Abstract excerpt

BACKGROUND: Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have one or two copies of the long (l) allele. Despite the reliability of this association, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arousal
Share to Depressive Disorder, Major
Share to Homozygote

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrocortisone

Share to Hypothalamo-Hypophyseal System

Share to Pituitary-Adrenal System

Share to Serotonin Plasma Membrane Transport Proteins

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 18005940
DOI: 10.1016/j.biopsych.2007.10.008
PMCID: PMC2373542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.PMID 18005940Read ↗

Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents.Semantic proximity Read ↗

Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression.Semantic proximity Read ↗

Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response.Semantic proximity Read ↗

Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).Semantic proximity Read ↗

Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: a daily process approach to gene-environment interaction.Semantic proximity Read ↗

Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction.Semantic proximity Read ↗

Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety.Semantic proximity Read ↗

Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression.Semantic proximity Read ↗

Serotonin transporter polymorphism predicts waking cortisol in young girls.Semantic proximity Read ↗

Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR).Semantic proximity Read ↗

An interaction between perceived stress and 5HTTLPR genotype in the prediction of stable depressive symptomatology.Semantic proximity Read ↗

Genes, stress, and depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.