Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety.

doi:10.1016/j.jpsychores.2005.06.068

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Article

Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety.

Journal of psychosomatic research - 1 Jan 2006

Mizuno Tomoko, Aoki Masashi, Shimada Yuko, Inoue Midori, Nakaya Kumi, Takahashi Toshiaki, Itoyama Yasuto, Kanazawa Motoyori, Utsumi Atsushi, Endo Yuka, Nomura Taisuke, Hiratsuka Masahiro, Mizugaki Michinao, Goto Junichi, Hongo Michio, Fukudo Shin

Abstract excerpt

OBJECTIVE: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. METHODS: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI),...

Topics

Adolescent
Adult
Affect
Aged
Anxiety Disorders
Chromosomes, Human, Pair 17
DNA Primers
Depression
Female
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Middle Aged

Polymorphism, Genetic

Promoter Regions, Genetic

Regulatory Sequences, Nucleic Acid

Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed

Identifiers

PMID: 16380315
DOI: 10.1016/j.jpsychores.2005.06.068

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16380315-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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