Article
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2008
Hsu Li-Chung, Ali Syed R, McGillivray Shauna, Tseng Ping-Hui, Mariathasan Sanjeev, Humke Eric W, Eckmann Lars, Powell Jonathan J, Nizet Victor, Dixit Vishva M, Karin Michael
Abstract excerpt
NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that was suggested to promote secretion of the proinflammatory cytokine IL-1beta. Yet, the molecular mechanism by which NOD2 can stimulate IL-1beta secretion, and its biological significance were heretofore unknown. We found that NOD2 through its N-terminal caspase recruitment domain directly binds and activates...
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