Article
Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures.
Nature genetics - 1 Jan 2008
Delneri Daniela, Hoyle David C, Gkargkas Konstantinos, Cross Emma J M, Rash Bharat, Zeef Leo, Leong Hui-Sun, Davey Hazel M, Hayes Andrew, Kell Douglas B, Griffith Gareth W, Oliver Stephen G
Abstract excerpt
Using competition experiments in continuous cultures grown in different nutrient environments (glucose limited, ammonium limited, phosphate limited and white grape juice), we identified genes that show haploinsufficiency phenotypes (reduced growth rate when hemizygous) or haploproficiency phenotypes (increased growth rate when hemizygous). Haploproficient genes (815, 1,194, 733 and 654 in glucose-limited,...
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