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Article

The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics.

Biochemistry - 22 Jan 2008

Rutherford Karen, Parson W W, Daggett Valerie

Abstract excerpt

Histamine N-methyltransferase (HNMT) is the primary enzyme responsible for inactivating histamine in the mammalian brain. The human HNMT gene contains a common threonine-isoleucine polymorphism at residue 105, distal from the active site. The 105I variant has decreased activity and lower protein levels than the 105T protein. Crystal structures of both variants have been determined but reveal little regarding how...

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Identifiers

PMID: 18154359
DOI: 10.1021/bi701737f
PMCID: PMC2905460

Genes

HNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics.PMID 18154359Read ↗

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