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Article

Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.

Journal of molecular biology - 13 Jun 2008

Rutherford Karen, Daggett Valerie

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) metabolizes cytotoxic thiopurine drugs used in the treatment of leukemia and inflammatory bowel disease. TPMT is a major pharmacogenomic target with 23 alleles identified to date. Several of these alleles cause rapid protein degradation and/or aggregation, making it extremely difficult to study the structural impact of the TPMT polymorphisms experimentally. We, therefore,...

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Share to Catalytic Domain
Share to Enzyme Stability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18482735
DOI: 10.1016/j.jmb.2008.04.032
PMCID: PMC2518407

Genes

TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.PMID 18482735Read ↗

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