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Article

Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.

Molecular pharmacology - 1 Apr 1998

Preuss C V, Wood T C, Szumlanski C L, Raftogianis R B, Otterness D M, Girard B, Scott M C, Weinshilboum R M

Abstract excerpt

Histamine N-methyltransferase (HNMT) catalyzes a major pathway in histamine metabolism. Levels of HNMT activity in humans are regulated by inheritance. We set out to study the molecular basis for this genetic regulation. Northern blot analysis showed that HNMT is highly expressed in the kidney, so we determined levels of enzyme activity and thermal stability in 127 human renal biopsy samples. DNA was isolated...

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Identifiers

PMID: 9547362
DOI: 10.1124/mol.53.4.708

Genes

HNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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