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Article

Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.

Diabetes - 1 Sept 2010

Brehm Michael A, Bortell Rita, Diiorio Philip, Leif Jean, Laning Joseph, Cuthbert Amy, Yang Chaoxing, Herlihy Mary, Burzenski Lisa, Gott Bruce, Foreman Oded, Powers Alvin C, Greiner Dale L, Shultz Leonard D

Abstract excerpt

OBJECTIVE: To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell-derived beta-cells in the absence or presence of a functional human immune system. RESEARCH DESIGN AND METHODS: We backcrossed the Ins2(Akita) m...

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Source

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Identifiers

PMID: 20570944
DOI: 10.2337/db10-0323
PMCID: PMC2927949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20570944-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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