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Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738) through enhancing interferon-beta.

Hepatology (Baltimore, Md.) - 1 Jul 2008

Hiasa Yoichi, Kuzuhara Hiroyuki, Tokumoto Yoshio, Konishi Ichiro, Yamashita Nobuyuki, Matsuura Bunzo, Michitaka Kojiro, Chung Raymond T, Onji Morikazu

Abstract excerpt

UNLABELLED: A derivative of soyasapogenol, 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738), ameliorates liver injury induced by Concanavalin A in mice. We examined whether ME3738 has independent antiviral effects against hepatitis C virus (HCV) using an established HCV replication model that expresses the full-length genotype 1a HCV complementary DNA plasmid (pT7-flHCV-Rz) under the control of a...

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PMID: 18459156
DOI: 10.1002/hep.22289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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