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Article

Mutual antagonism between circadian protein period 2 and hepatitis C virus replication in hepatocytes.

PloS one - 1 Jan 2013

Benegiamo Giorgia, Mazzoccoli Gianluigi, Cappello Francesco, Rappa Francesca, Scibetta Nunzia, Oben Jude, Greco Azzura, Williams Roger, Andriulli Angelo, Vinciguerra Manlio, Pazienza Valerio

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) infects approximately 3% of the world population and is the leading cause of liver disease, impacting hepatocyte metabolism, depending on virus genotype. Hepatic metabolic functions show rhythmic fluctuations with 24-h periodicity (circadian), driven by molecul...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23593233
DOI: 10.1371/journal.pone.0060527
PMCID: PMC3620463

Genes

PER2
CRY2
CLOCK
CRY1
PER1
PER3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23593233-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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