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Article

The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy.

Leukemia - 1 Mar 2008

Ge Y, LaFiura K M, Dombkowski A A, Chen Q, Payton S G, Buck S A, Salagrama S, Diakiw A E, Matherly L H, Taub J W

Abstract excerpt

Acute myeloid leukemia (AML) in Down syndrome (DS) children has several unique features including a predominance of the acute megakaryocytic leukemia (AMkL) phenotype, higher event-free survivals compared to non-DS children using cytosine arabinoside (ara-C)/anthracycline-based protocols and a uniform presence of somatic mutations in the X-linked transcription factor gene, GATA1. Several chromosome 21-localized...

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Source

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Identifiers

PMID: 18094719
DOI: 10.1038/sj.leu.2405066
PMCID: PMC3809919

Genes

ETS2
GATA1
CSF2
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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