Article
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2006
Bourquin Jean-Pierre, Subramanian Aravind, Langebrake Claudia, Reinhardt Dirk, Bernard Olivier, Ballerini Paola, Baruchel André, Cavé Hélène, Dastugue Nicole, Hasle Henrik, Kaspers Gertjan L, Lessard Michel, Michaux Lucienne, Vyas Paresh, van Wering Elisabeth, Zwaan Christian M, Golub Todd R, Orkin Stuart H
Abstract excerpt
Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by expression of truncated GATA1 transcription factor protein (GATA1s) due to somatic mutation. The treatment outcome for DS-AMKL is more favorable than for AMKL in non-DS patients. To gain insight into gene expression differences in AMKL, we compared 24 DS and 39 non-DS AMKL samples. We found that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.