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BRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trials.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2007

Tilanus-Linthorst Madeleine M A, Obdeijn Inge-Marie, Hop Wim C J, Causer Petrina A, Leach Martin O, Warner Ellen, Pointon Linda, Hill Kimberley, Klijn Jan G M, Warren Ruth M L, Gilbert Fiona J

Abstract excerpt

PURPOSE: Magnetic resonance imaging (MRI) screening enables early detection of breast cancers in women with an inherited predisposition. Interval cancers occurred in women with a BRCA1 mutation, possibly due to fast tumor growth. We investigated the effect of a BRCA1 or BRCA2 mutation and age on the growth rate of breast cancers, as this may influence the optimal screening frequency. EXPERIMENTAL DESIGN: We...

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PMID: 18094417
DOI: 10.1158/1078-0432.CCR-07-0689

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BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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