Article
Differences in natural history between breast cancers in BRCA1 and BRCA2 mutation carriers and effects of MRI screening-MRISC, MARIBS, and Canadian studies combined.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2012
Heijnsdijk Eveline A M, Warner Ellen, Gilbert Fiona J, Tilanus-Linthorst Madeleine M A, Evans Gareth, Causer Petrina A, Eeles Rosalind A, Kaas Reinie, Draisma Gerrit, Ramsay Elizabeth A, Warren Ruth M L, Hill Kimberly A, Hoogerbrugge Nicoline, Wasser Martin N J M, Bergers Elisabeth, Oosterwijk Jan C, Hooning Maartje J, Rutgers Emiel J T, Klijn Jan G M, Plewes Don B, Leach Martin O, de Koning Harry J
Abstract excerpt
BACKGROUND: It is recommended that BRCA1/2 mutation carriers undergo breast cancer screening using MRI because of their very high cancer risk and the high sensitivity of MRI in detecting invasive cancers. Clinical observations suggest important differences in the natural history between breast cancers due to mutations in BRCA1 and BRCA2, potentially requiring different screening guidelines. METHODS: Three studies...
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