Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers.

doi:10.1158/1078-0432.CCR-18-0200

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Article

Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2019

Guindalini Rodrigo Santa Cruz, Zheng Yonglan, Abe Hiroyuki, Whitaker Kristen, Yoshimatsu Toshio F, Walsh Tom, Schacht David, Kulkarni Kirti, Sheth Deepa, Verp Marion S, Bradbury Angela R, Churpek Jane, Obeid Elias, Mueller Jeffrey, Khramtsova Galina, Liu Fang, Raoul Akila, Cao Hongyuan, Romero Iris L, Hong Susan, Livingston Robert, Jaskowiak Nora, Wang Xiaoming, Debiasi Marcio, Pritchard Colin C, King Mary-Claire, Karczmar Gregory, Newstead Gillian M, Huo Dezheng, Olopade Olufunmilayo I

Abstract excerpt

PURPOSE: To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer.Experimental Design: We performed dynamic contrast-enhanced MRI every 6 months in conjunction with annual mammography (MG). Eligible participants had a cumulative lifetime breast cancer risk ≥20% and/or tested positive for a pathogenic mutation in a known breast cancer susceptibility gene. RESULTS: Between 2004...

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PMID: 30154229
DOI: 10.1158/1078-0432.CCR-18-0200
PMCID: PMC6395536

Genes

BRCA1
BRCA2
CDH1

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