Article
Relevance and efficacy of breast cancer screening in BRCA1 and BRCA2 mutation carriers above 60 years: a national cohort study.
International journal of cancer - 15 Dec 2014
Saadatmand Sepideh, Vos Janet R, Hooning Maartje J, Oosterwijk Jan C, Koppert Linetta B, de Bock Geertruida H, Ausems Margreet G, van Asperen Christi J, Aalfs Cora M, Gómez Garcia Encarna B, Meijers-Heijboer Hanne, Hoogerbrugge Nicoline, Piek Marianne, Seynaeve Caroline, Verhoef Cornelis, Rookus Matti, Tilanus-Linthorst Madeleine M
Abstract excerpt
Annual MRI and mammography is recommended for BRCA1/2 mutation carriers to reduce breast cancer mortality. Less intensive screening is advised ≥60 years, although effectiveness is unknown. We identified BRCA1/2 mutation carriers without bilateral mastectomy before age 60 to determine for whom screening ≥60 is relevant, in the Rotterdam Family Cancer Clinic and HEBON: a nationwide prospective cohort study....
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