BRCA1-associated breast cancers present differently from BRCA2-associated and familial cases: long-term follow-up of the Dutch MRISC Screening Study.

doi:10.1200/JCO.2009.27.2294

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Article

BRCA1-associated breast cancers present differently from BRCA2-associated and familial cases: long-term follow-up of the Dutch MRISC Screening Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Dec 2010

Rijnsburger Adriana J, Obdeijn Inge-Marie, Kaas Reinoutje, Tilanus-Linthorst Madeleine M A, Boetes Carla, Loo Claudette E, Wasser Martin N J M, Bergers Elisabeth, Kok Theo, Muller Sara H, Peterse Hans, Tollenaar Rob A E M, Hoogerbrugge Nicoline, Meijer Sybren, Bartels Carina C M, Seynaeve Caroline, Hooning Maartje J, Kriege Mieke, Schmitz Paul I M, Oosterwijk Jan C, de Koning Harry J, Rutgers Emiel J T, Klijn Jan G M

Abstract excerpt

PURPOSE: The Dutch MRI Screening Study on early detection of hereditary breast cancer started in 1999. We evaluated the long-term results including separate analyses of BRCA1 and BRCA2 mutation carriers and first results on survival. PATIENTS AND METHODS: Women with higher than 15% cumulative lifetime risk (CLTR) of breast cancer were screened with biannual clinical breast examination and annual mammography and...

Topics

Adult
Aged
Breast Neoplasms
Female
Follow-Up Studies
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Magnetic Resonance Imaging

Mammography

Mass Screening

Middle Aged

Mutation

Physical Examination

Prospective Studies

Source

Open in PubMed

Identifiers

PMID: 21079137
DOI: 10.1200/JCO.2009.27.2294

Genes

BRCA1
BRCA2

Provenance

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