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Article

Contribution of mammography to MRI screening in BRCA mutation carriers by BRCA status and age: individual patient data meta-analysis.

British journal of cancer - 15 Mar 2016

Phi Xuan-Anh, Saadatmand Sepideh, De Bock Geertruida H, Warner Ellen, Sardanelli Francesco, Leach Martin O, Riedl Christopher C, Trop Isabelle, Hooning Maartje J, Mandel Rodica, Santoro Filippo, Kwan-Lim Gek, Helbich Thomas H, Tilanus-Linthorst Madeleine M A, van den Heuvel Edwin R, Houssami Nehmat

Abstract excerpt

BACKGROUND: We investigated the additional contribution of mammography to screening accuracy in BRCA1/2 mutation carriers screened with MRI at different ages using individual patient data from six high-risk screening trials. METHODS: Sensitivity and specificity of MRI, mammography and the combination of these tests were compared stratified for BRCA mutation and age using generalised linear mixed models with...

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Identifiers

PMID: 26908327
DOI: 10.1038/bjc.2016.32
PMCID: PMC4800299

Genes

BRCA1
BRCA2

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