Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination.

Molecular biology of the cell - 1 Mar 2008

Hirayama Shoshiro, Yamazaki Yuji, Kitamura Akira, Oda Yukako, Morito Daisuke, Okawa Katsuya, Kimura Hiroshi, Cyr Douglas M, Kubota Hiroshi, Nagata Kazuhiro

Abstract excerpt

McKusick-Kaufman syndrome (MKKS) is a recessively inherited human genetic disease characterized by several developmental anomalies. Mutations in the MKKS gene also cause Bardet-Biedl syndrome (BBS), a genetically heterogeneous disorder with pleiotropic symptoms. However, little is known about how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bardet-Biedl Syndrome
Share to Centrosome
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubules

Share to Proteasome Inhibitors

Share to Protein Structure, Quaternary

Share to Solubility

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 18094050
DOI: 10.1091/mbc.e07-07-0631
PMCID: PMC2262992

Genes

MKKS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18094050-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination.PMID 18094050Read ↗

MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.Semantic proximity Read ↗

Preventing the Degradation of Mps1 at Centrosomes Is Sufficient to Cause Centrosome Reduplication in Human CellsSemantic proximity Read ↗

Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.Semantic proximity Read ↗

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of cerebellar CHIPopathySemantic proximity Read ↗

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome functionSemantic proximity Read ↗

In vitro reconstitution of minimal human centrosomesSemantic proximity Read ↗

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression.Semantic proximity Read ↗

Mps1 as a link between centrosomes and genomic instability.Semantic proximity Read ↗

Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein).Semantic proximity Read ↗

TRIM37 recognizes a bipartite degron to ubiquitinate centrosome substratesSemantic proximity Read ↗

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.Semantic proximity Read ↗

Phosphoregulation of human Mps1 kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.