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Article

The deletion of amino acids 114-121 in the TM1 domain of mouse prion protein stabilizes its conformation but does not affect the overall structure.

Biochimica et biophysica acta - 1 Jun 2008

Thaa Bastian, Zahn Ralph, Matthey Ulrich, Kroneck Peter M H, Bürkle Alexander, Fritz Günter

Abstract excerpt

A mutant of mouse prion protein (PrPC) carrying a deletion of residues 114-121 (PrPDelta114-121) has previously been described to lack convertibility into the scrapie-associated isoform of PrP (PrPSc) and to exhibit a dominant-negative effect on the conversion of wild-type PrPC into PrPSc in living cells. Here we report the characterization of recombinantly expressed PrPDelta114-121 by Fourier-transformation...

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PMID: 18088603
DOI: 10.1016/j.bbamcr.2007.11.007

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