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Article

Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations.

European journal of biochemistry - 1 Dec 2001

Daniels M, Cereghetti G M, Brown D R

Abstract excerpt

Mice expressing a C-terminal fragment of the prion protein instead of wild-type prion protein die from massive neuronal degeneration within weeks of birth. The C-terminal region of PrPc (PrP121-231) expressed in these mice has an intrinsic neurotoxicity to cultured neurones. Unlike PrPSc, which i...

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Source

Identifiers

PMID: 11733010
DOI: 10.1046/j.0014-2956.2001.02567.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11733010-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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