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Article

Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes.

Human molecular genetics - 15 Apr 2017

Russo Arianna, Scardigli Raffaella, La Regina Federico, Murray Melissa E, Romano Nicla, Dickson Dennis W, Wolozin Benjamin, Cattaneo Antonino, Ceci Marcello

Abstract excerpt

TDP-43 is a well known RNA binding protein involved in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Dementia (FTLD). In physiological conditions, TDP-43 mainly localizes in the nucleus and shuttles, at least in neurons, to the cytoplasm to form TDP-43 RNA granules. In the nucleus, TDP-43 participates to the expression and splicing of RNAs, while in the cytoplasm its functions...

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Source

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Identifiers

PMID: 28158562
DOI: 10.1093/hmg/ddx035
PMCID: PMC6075552

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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