Article
Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2007
Beesley Jonathan, Jordan Susan J, Spurdle Amanda B, Song Honglin, Ramus Susan J, Kjaer Suzanne Kruger, Hogdall Estrid, DiCioccio Richard A, McGuire Valerie, Whittemore Alice S, Gayther Simon A, Pharoah Paul D P, Webb Penelope M, Chenevix-Trench Georgia
Abstract excerpt
Although some high-risk ovarian cancer genes have been identified, it is likely that common low penetrance alleles exist that confer some increase in ovarian cancer risk. We have genotyped nine putative functional single-nucleotide polymorphisms (SNP) in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian...
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