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SRD5A2 gene polymorphisms affect the risk of breast cancer.

Breast (Edinburgh, Scotland) - 1 Apr 2014

Francis Amirtharaj, Sarkar Saumya, Pooja Singh, Surekha Daminani, Rao Digumarthi Raghunatha, Rao Lakshmi, Ramachandra Lingadakai, Vishnupriya Satti, Satyamoorthy Kapaettu, Thangaraj Kumarasamy, Rajender Singh

Abstract excerpt

Androgens in breast cancer have been studied alone and in correlation with estrogens as estrogen to testosterone ratio. 5-α-reductase is one of the important enzymes participating in androgen metabolism, which affects androgen activity by affecting conversion of testosterone to dihydrotestosterone. We hypothesized that polymorphisms in the SRD5A2 gene (encoding 5-α-reductase) may affect breast cancer risk by...

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PMID: 24365257
DOI: 10.1016/j.breast.2013.11.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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