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Article

Polymorphisms in DNA repair genes and epithelial ovarian cancer risk.

International journal of cancer - 20 Nov 2005

Auranen Annika, Song Honglin, Waterfall Christy, Dicioccio Richard A, Kuschel Bettina, Kjaer Susanne K, Hogdall Estrid, Hogdall Claus, Stratton John, Whittemore Alice S, Easton Douglas F, Ponder Bruce A J, Novik Karen L, Dunning Alison M, Gayther Simon, Pharoah Paul D P

Abstract excerpt

DNA repair gene polymorphisms and mutations are known to influence cancer risk. We studied whether polymorphisms in DNA double strand break (DSB) repair genes are associated with epithelial ovarian cancer (EOC) risk. Up to 1,600 cases and 4,241 controls from 4 separate genetic association studies from 3 countries were genotyped for 13 single nucleotide polymorphisms (SNP) in 6 genes (BRCA1, NBS1, RAD51, RAD52,...

Topics

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Case-Control Studies
Base Sequence
DNA Primers
DNA Repair
Neoplasms, Glandular and Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Polymorphism, Genetic

Source

Identifiers

PMID: 15924337
DOI: 10.1002/ijc.21047

Genes

XRCC3
XRCC2
BRCA1
RAD51
RAD52

Variants

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