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Article

Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review.

American journal of epidemiology - 1 Jan 2010

Li Jun, Coates Ralph J, Gwinn Marta, Khoury Muin J

Abstract excerpt

Steroid 5-alpha-reductase type 2 (SRD5a2) is a critical enzyme in androgen metabolism. Two polymorphisms in the SRD5a2 gene, V89L (rs523349) and A49T (rs9282858), have been studied for associations with prostate cancer risk, with conflicting results. The authors conducted a systematic review and meta-analysis (1997-2007) to examine these associations and compared the results with findings from genome-wide...

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3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Androgens
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Markers

Prostatic Hyperplasia

Prostatic Neoplasms

Risk Assessment

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PMID: 19914946
DOI: 10.1093/aje/kwp318

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Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review.PMID 19914946Read ↗

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