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Article

Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes by 2-aminopurine.

Nucleic acids research - 1 Feb 2008

Avilov S V, Piemont E, Shvadchak V, de Rocquigny H, Mély Y

Abstract excerpt

The nucleocapsid protein (NC) plays an important role in HIV-1, mainly through interactions with the genomic RNA and its DNA copies. Though the structures of several complexes of NC with oligonucleotides (ODNs) are known, detailed information on the ODN dynamics in the complexes is missing. To address this, we investigated the steady state and time-resolved fluorescence properties of 2-aminopurine (2Ap), a...

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Identifiers

PMID: 18086707
DOI: 10.1093/nar/gkm1109
PMCID: PMC2241888

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