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Article

Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.

Journal of molecular biology - 20 May 2005

Beltz Hervé, Clauss Céline, Piémont Etienne, Ficheux Damien, Gorelick Robert J, Roques Bernard, Gabus Caroline, Darlix Jean-Luc, de Rocquigny Hugues, Mély Yves

Abstract excerpt

The nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) is formed of two highly conserved CCHC zinc fingers flanked by small basic domains. NC is required for the two obligatory strand transfers in viral DNA synthesis through its nucleic acid chaperoning properties. The first DNA strand transfer relies on NC's ability to bind and destabilize the secondary structure of complementary...

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Share to Capsid Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to Protein Folding

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Source

Identifiers

PMID: 15854648
DOI: 10.1016/j.jmb.2005.02.042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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