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Article

Potential Intra- and Intermolecular Interactions Involving the Unique-5′ Region of the HIV-1 5′-UTR

12 Nov 2008

Abstract excerpt

The 5'-untranslated region (5'-UTR) of the human immunodeficiency virus type-1 (HIV-1) genome regulates multiple RNA-dependent functions during viral replication and has been proposed to adopt multiple secondary structures. Recent phylogenetic studies identified base pair complementarity between residues of the unique 5' element and those near the gag start codon (gag(AUG)) that is conserved among evolutionarily...

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PMID: 19006324
DOI: 10.1021/bi8014373

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