Article
Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).
Journal of molecular biology - 23 Oct 1998
Morellet N, Déméné H, Teilleux V, Huynh-Dinh T, de Rocquigny H, Fournié-Zaluski M C, Roques B P
Abstract excerpt
The nucleocapsid protein NCp7 of HIV-1 Mal contains two successive Zn knuckles of the CX2CX4HX4C type and plays a major role in virion morphogenesis, genomic RNA packaging and viral infectivity, mainly through single-stranded nucleic acid binding. We report here the study by 1H 2D NMR of the comp...
Topics
- Amino Acid Sequence
- Capsid
- Capsid Proteins
- Gene Products, gag
- HIV-1
- Macromolecular Substances
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides
- Protein Conformation
- Spectrometry, Fluorescence
- Viral Proteins
- Zinc
- gag Gene Products, Human Immunodeficiency Virus