Article
Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.
Nucleic acids research - 1 Aug 2011
Godet Julien, Ramalanjaona Nick, Sharma Kamal K, Richert Ludovic, de Rocquigny Hugues, Darlix Jean-Luc, Duportail Guy, Mély Yves
Abstract excerpt
Synthesis of the HIV-1 viral DNA by reverse transcriptase involves two obligatory strand transfer reactions. The second strand transfer corresponds to the annealing of the (-) and (+) DNA copies of the primer binding site (PBS) sequence which is chaperoned by the nucleocapsid protein (NCp7). NCp7 modifies the (+)/(-)PBS annealing mechanism by activating a loop-loop kissing pathway that is negligible without NCp7....
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