Derivation of infectious HIV-1 molecular clones with LTR mutations: sensitivity to the CD8+ cell noncytotoxic anti-HIV response.

doi:10.1016/j.virol.2007.11.003

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Article

Derivation of infectious HIV-1 molecular clones with LTR mutations: sensitivity to the CD8+ cell noncytotoxic anti-HIV response.

Virology - 30 Mar 2008

Bonneau Kyle R, Ng Sharon, Foster Hillary, Choi Kelly B, Berkhout Ben, Rabson Arnold, Mackewicz Carl E, Levy Jay A

Abstract excerpt

CD8(+) cells from healthy, asymptomatic HIV-1-infected individuals can inhibit HIV-1 replication in naturally or acutely infected CD4(+) cells in the absence of cell killing. This CD8(+) cell noncytotoxic anti-HIV response (CNAR) is mediated by a soluble CD8(+) cell antiviral factor (CAF). CNAR/CAF inhibits HIV-1 replication by blocking viral RNA transcription. HIV transcription is regulated by a variety of...

Topics

Antiviral Agents
Base Sequence
CD8-Positive T-Lymphocytes
Cloning, Molecular
HIV Infections
HIV Long Terminal Repeat
HIV Seropositivity
HIV-1
Humans
Molecular Sequence Data
Mutation
Virus Replication

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Identifiers

PMID: 18086484
DOI: 10.1016/j.virol.2007.11.003

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