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CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription.

14 Mar 1995

Abstract excerpt

CD8+ cells from human immunodeficiency virus (HIV)-infected individuals suppress HIV replication in cultured CD4+ cells by a noncytolytic mechanism that involves a secreted CD8(+)-cell antiviral factor (CAF). The results of this study suggest that CD8+ cells, as well as CAF, arrest HIV replication at the level of viral transcription. Culturing naturally infected CD4+ cells actively producing HIV with autologous...

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PMID: 7534418
DOI: 10.1073/pnas.92.6.2308

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