Article
A novel HIV-1 isolate containing alterations affecting the NF-kappa B element.
Virology - 1 Mar 1991
Englund G, Hoggan M D, Theodore T S, Martin M A
Abstract excerpt
Three molecular clones of HIV-1, derived from a single isolate (AL1), exhibited distinct replicative and cytopathic properties during propagation in a human T cell line. The phenotypic differences observed were attributable, in large part, to changes affecting the viral LTR. Nucleotide sequence and PCR analyses demonstrated the presence of novel duplications or deletions involving the NF-kappa B motif. These...
Topics
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Genetic Variation
- HIV Enhancer
- HIV Long Terminal Repeat
- HIV-1
- Humans
- Kinetics
- Molecular Sequence Data
- NF-kappa B