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Article

Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.

Brain research bulletin - 30 Apr 2007

Vatsavayai Sarat C, Dallérac Glenn M, Milnerwood Austen J, Cummings Damian M, Rezaie Payam, Murphy Kerry P S J, Hirst Mark C

Abstract excerpt

Transgenic models representing Huntington's disease (HD) have proved useful for understanding the cascade of molecular events leading to the disease. We report an initial characterisation of a novel transgenic mouse model derived from a spontaneous truncation event within the R6/1 transgene. The transgene is widely expressed, carries 89 CAG repeats and the animals exhibit a significantly milder neurological...

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Identifiers

PMID: 17352932
DOI: 10.1016/j.brainresbull.2006.10.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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