Gamma-butyrolactone-dependent expression of the Streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei.

doi:10.1128/JB.01383-07

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Gamma-butyrolactone-dependent expression of the Streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei.

Journal of bacteriology - 1 Feb 2008

Yamamoto Shouji, He Yuxi, Arakawa Kenji, Kinashi Haruyasu

Abstract excerpt

Our previous studies revealed that the srrX and srrA genes carried on the large linear plasmid pSLA2-L constitute a gamma-butyrolactone-receptor system in Streptomyces rochei. Extensive transcriptional analysis has now showed that the Streptomyces antibiotic regulatory protein gene srrY, which is also carried on pSLA2-L, is a target of the receptor/repressor SrrA and plays a central role in lankacidin and...

Topics

4-Butyrolactone
Anti-Bacterial Agents
Bacterial Proteins
Binding Sites
DNA Fingerprinting
Electrophoretic Mobility Shift Assay
Erythromycin
Gene Expression Regulation, Bacterial
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrolides

Mutagenesis

Mutation

Plasmids

Polymerase Chain Reaction

Protein Binding

Streptomyces

Source

Open in PubMed Open full text

Identifiers

PMID: 18083808
DOI: 10.1128/JB.01383-07
PMCID: PMC2238197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gamma-butyrolactone-dependent expression of the Streptomyces antibiotic regulatory protein gene srrY plays a central role in the regulatory cascade leading to lankacidin and lankamycin production in Streptomyces rochei.PMID 18083808Read ↗

Functional Analysis of P450 Monooxygenase SrrO in the Biosynthesis of Butenolide-Type Signaling Molecules in Streptomycesrochei.Semantic proximity Read ↗

Gamma-butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation.Semantic proximity Read ↗

Pleiotropic Functions of a Streptomyces pristinaespiralis Autoregulator Receptor in Development, Antibiotic Biosynthesis, and Expression of a Superoxide DismutaseSemantic proximity Read ↗

Isolation and characterization of linear plasmids from lankacidin-producing Streptomyces species.Semantic proximity Read ↗

Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.Semantic proximity Read ↗

A putative redox‐sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensisSemantic proximity Read ↗

Beyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesisSemantic proximity Read ↗

Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.Semantic proximity Read ↗

The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensisSemantic proximity Read ↗

Characterization of mutations in regulatory genes of Tyl cluster leading to overexpression of tylosin in mutant γ-1 of Streptomyces fradiae NRRL-2702.Semantic proximity Read ↗

Characterisation of a natural variant of the γ-butyrolactone signalling receptor.Semantic proximity Read ↗

Improvement of rimocidin production in Streptomyces rimosus M527 by reporter-guided mutation selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.