Article
Isolation and characterization of linear plasmids from lankacidin-producing Streptomyces species.
The Journal of antibiotics - 1 Dec 1994
Kinashi H, Mori E, Hatani A, Nimi O
Abstract excerpt
Streptomyces rochei 7434AN4, a producer of lankacidin and lankamycin contains three large linear plasmids, pSLA2-L (200 kb), M (100 kb), and S (17 kb). Studies on the mutants of 7434AN4 having a different plasmid profile showed a parallel relationship between the presence of pSLA2-L and the production of both lankacidin and lankamycin. When pSLA2-L was transferred by protoplast fusion to S. rochei 2-39, a...
Topics
- Anti-Bacterial Agents
- Antibiotics, Antineoplastic
- Electrophoresis, Agar Gel
- Electrophoresis, Polyacrylamide Gel
- Macrolides
- Mutation
- Plasmids
- Protoplasts
- Restriction Mapping
- Streptomyces