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Article

SPICE: discovery of phenotype-determining component interplays.

BMC systems biology - 14 May 2012

Chen Zhengzhang, Padmanabhan Kanchana, Rocha Andrea M, Shpanskaya Yekaterina, Mihelcic James R, Scott Kathleen, Samatova Nagiza F

Abstract excerpt

BACKGROUND: A latent behavior of a biological cell is complex. Deriving the underlying simplicity, or the fundamental rules governing this behavior has been the Holy Grail of systems biology. Data-driven prediction of the system components and their component interplays that are responsible for the target system's phenotype is a key and challenging step in this endeavor. RESULTS: The proposed approach, which we...

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Identifiers

PMID: 22583800
DOI: 10.1186/1752-0509-6-40
PMCID: PMC3515406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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