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Article

Cloning and functional characterization of the human fractalkine receptor promoter regions

15 Dec 2002

Abstract excerpt

We have previously shown that reduced expression of the fractalkine receptor, CX3CR1, is correlated with rapid HIV disease progression and with reduced susceptibility to acute coronary events. In order to elucidate the mechanisms underlying transcriptional regulation of CX3CR1 expression, we structurally and functionally characterized the CX3CR1 gene. It consists of four exons and three introns spanning over 18...

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PMID: 12234253
DOI: 10.1042/bj20020951

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