Article
Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana.
Molecular & cellular proteomics : MCP - 1 Mar 2015
Roitinger Elisabeth, Hofer Manuel, Köcher Thomas, Pichler Peter, Novatchkova Maria, Yang Jianhua, Schlögelhofer Peter, Mechtler Karl
Abstract excerpt
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues is an important biological regulatory mechanism. In the context of genome integrity, signaling cascades driven by phosphorylation are crucial for the coordination and regulation of DNA repair. The two serine/threonine protein kinases ataxia telangiectasia-mutated (ATM) and Ataxia telangiectasia-mutated and Rad3-related (ATR)...
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