Article
A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples.
Molecular psychiatry - 1 Jul 2016
Cohen O S, Weickert T W, Hess J L, Paish L M, McCoy S Y, Rothmond D A, Galletly C, Liu D, Weinberg D D, Huang X-F, Xu Q, Shen Y, Zhang D, Yue W, Yan J, Wang L, Lu T, He L, Shi Y, Xu M, Che R, Tang W, Chen C-H, Chang W-H, Hwu H-G, Liu C-M, Liu Y-L, Wen C-C, Fann C S-J, Chang C-C, Kanazawa T, Middleton F A, Duncan T M, Faraone S V, Weickert C S, Tsuang M T, Glatt S J
Abstract excerpt
The rs1076560 polymorphism of DRD2 (encoding dopamine receptor D2) is associated with alternative splicing and cognitive functioning; however, a mechanistic relationship to schizophrenia has not been shown. Here, we demonstrate that rs1076560(T) imparts a small but reliable risk for schizophrenia in a sample of 616 affected families and five independent replication samples totaling 4017 affected and 4704...
Read the complete abstract on PubMed