Article
The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
Endocrinology - 1 Nov 1997
Vollenweider P, Martin S S, Haruta T, Morris A J, Nelson J G, Cormont M, Le Marchand-Brustel Y, Rose D W, Olefsky J M
Abstract excerpt
Insulin's stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter GLUT4 to the plasma membrane. Small GTP-binding proteins have been implicated in the regulation of vesicular traffic. We studied the effects of microinjection of wild-type Rab4 glu...
Topics
- 3T3 Cells
- Actins
- Adipocytes
- Animals
- Antibodies
- Biological Transport
- Blotting, Western
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Glucose Transporter Type 4
- Glutathione Transferase
- Insulin
- Mice
- Microinjections